Accueil du site > Equipes > Fonctionnalité et dynamique du tissu cutané (D. Sigaudo-Roussel) > Thématiques > Marqueurs cutanés du stress > Cutaneous markers of stress
Project leaders : C. Viart-Ferber, P. Cochat, L. Dubourg
Persons involved in the project : P. Sommer, R. Debret, A. Josset-Lamaugarny, D. Vital-Durand, J.L. Saumet, D. Sigaudo-Roussel, N. Guffon, Froissart R, C. Gauthier, C. Acquaviva.
Predictor of plantar ulcer
Despite numerous studies of prevention and treatment of plantar ulcer made over the past two decades, the rate of lower limb amputation remains high in diabetic patients (15 times) compared to non-diabetic patients. 15% of diabetics have a plantar ulcer during their life, associated with a risk of amputation and mortality 2 times higher than the diabetic population without plantar ulcer. Predicting the occurrence of plantar ulcer is limited and only the occurrence of a wound on diabetic foot involves assessment and treatment.
We have shown that a combination of peripheral vascular damage and neuropathy makes diabetic patients particularly sensitive to foot ulceration. We want to show that alterations in the pressure-induced vasodilatation (PIV) are associated with the presence of a plantar ulcer, taking into account the influence of age and neuropathy in diabetic patients.
PIV validation test will provide an indicator of high risk of plantar ulcer. In addition, PIV provides an opportunity to evaluate the benefit of therapy performed on a patient at risk for plantar ulcer without having to wait for the appearance of the ulcer and will thus follow therapeutic management strategies. This study is conducted in collaboration with the Department of Diabetes and financed by the "Cluster 11" of the Rhône-Alpes Region.
Skin marker informing on deep organs alterations
With our expertise in the assessment of skin microcirculation and in the study of cutaneous complications pathological condition, we assume that the non-invasive neurovascular exploration of the skin may be an early marker of damage to other organs targeted by pathological processes.
We focus on two rare disease, the "Fabry disease" and "oxalosis" that specifically lead to severe kidney disease often requiring kidney transplant. For both diseases there are no early non-invasive marker to assess the progression of the disease stage. But skin is visibly affected by accumulation of glycosphingolipid Gb3 for Fabry disease and oxalate accumulation in oxalosis.
The study focuses on an exploration of the microcirculation and cutaneous-neurovascular interactions coupled with the annual report (kidney, heart and brain) of Fabry patients and oxalosis to assess the possibility of using skin as a "marker" for these two diseases. This project is made possible thanks to Pierre Cochat, coordinator of the Centre for Rare Diseases and oxalosis European expert in pathology, and Nathalie Guffon, Centre Coordinator of rare diseases for Fabry disease. Both networks allow us an optimal patient recruitment.
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