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Accueil du site > Equipes > Vecteurs colloïdaux et transport tissulaire (B. Verrier) > Thématiques > Conception de colloïdes intelligents > Conception of intelligent colloids

Conception of intelligent colloids

Project leader(s) : T. Trimaille, B. Verrier

People involved in the project : V. Lahaye, D. Ficheux, S. Megy, A. S. Boisgard

The development of intelligent nanoparticles relies on a strategy of targeting inspired from viruses and the design of a tunable polymer architecture. To reach this goal, we work on both the encapsulation of drugs able to interact with the intracellular signaling pathways, such as TLR (Toll Like Receptor) ligand cascade (TLR3, TLR 5&7) or NOD ((Nucleotide Oligomerization binding Domain) ligand cascade and specific cell targeting.

The surface functionalization is achieved by passive adsorption on poly(lactic acid) (PLA) nanoparticles of controlled size (120 to 260 nm) of viral antigens, proteins allowing to confer stealthness or specific antibodies. More specifically, we will focus on the following aspects :

  • Synthesis of PLA nanoparticles and micellar systems (amphiphilic block copolymers), fluorescent (or not), by nanoprecipitation (green chemistry) enabling encapsulation of drugs (antiretroviral drugs, TLR / NOD ligands), and control of size,
  • Functionalization of nanoparticles (via amphiphilic copolymers) for covalent coupling of immunostimulating peptides or peptides enabling diffusion in a fibril network (RGD, integrins,…).

Biomimetic particulate systems based on poly (lactic acid)

References :

Elaboration of Glycopolymer-Functionalized Micelles from an N-Vinylpyrrolidone/Lactide-Based Reactive Copolymer Platform. 
Handké N, Lahaye V, Bertin D, Delair T, Verrier B, Gigmes D, Trimaille T.
(2013) Macromol Biosci 

Lysine-tagged peptide coupling onto polylactide nanoparticles coated with activated ester-based amphiphilic copolymer : a route to highly peptide-functionalized biodegradable carriers.
Handké N, Ficheux D, Rollet M, Delair T, Mabrouk K, Bertin D, Gigmes D, Verrier B, Trimaille T.
(2012) Colloids Surf B Biointerfaces 103:298-303.

Encapsulation of Nod1 and Nod2 receptor ligands into poly(lactic acid) nanoparticles potentiates their immune properties.
Pavot V, Rochereau N, Primard C, Genin C, Perouzel E, Lioux T, Paul S, Verrier B.
(2013) J Control Release 167(1):60-7.

Elaboration Of Densely Functionalized Polylactide Nanoparticles From N-acryloxysuccinimide-based Block Copolymers
Handke N, Trimaille T, Luciani E, Rollet M, Delair T, Verrier B, Bertin D, Gigmes D,
(2011) Journal Of Polymer Science Part A-Polymer Chemistry 49 : 1341-1350

Particules formées d’un complexe polyélectrolyte de chitosane et d’un polysaccharide anionique, présentant une stabilité améliorée
Gaudin, F., Delair T., Verrier, B. 2010. Patent, FR-0143-00-07T00

Collaborations within the Institut :

P. Sommer, R. Debret

Collaborations and financial supports :

Pr. Thierry DELAIR
Université Lyon-1,
Laboratoire des Matériaux Polymères et des Biomatériaux,
Bat. ISTIL, 15, bd. A. Latarjet,
F-69622 Villeurbanne Cedex, France,

Equipe Chimie Radicalaire Organique et Polymères de Spécialité

Aix-Marseille Université
Institut de Chimie Radicalaire (UMR 7273)
Av. Escadrille Normandie Niemen
F-13397 Marseille Cedex 20, France

ANABIO : Design of pharmaceutical nanoparticles astoire subunit vaccine adjuvant
Coordinator : Dr. Bernard Verrier
UMR 5305- Lyon, France

Pecsdeli : Development of intelligent colloids for mucosal drug delivery
Coordinator : Pr. Thierry Delair
IMP, UMR 5223, Université Lyon

iNanoDCs : Design of multifunctional nanoparticles targeting TLR or Nod receptors for dendritic cell immune therapy
Coordinator : Dr. Bernard Verrier
UMR 5305- Lyon, France

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