BMSSI : Bases Moléculaires et Structurales des Systèmes Infectieux - UMR 5086

7èmes Journées du Groupe de Réflexion en Ingénierie Tissulaire

2013-04-25T07:24:23Z

Colloque d'une journée consacré à l'ingénierie tissulaire (incluant biomatériaux, ingénierie, biologie et médecine régénératrice). Ce colloque aura lieu le 13 juin à la faculté dentaire de Montrouge, et est l'occasion de dresser un bilan de l'ingénierie tissulaire en France.

Contact : F Mallein-Gerin (LBTI)

Appel à candidature pour le directeur de l'Unité BMSSI UMR 5086

2013-04-08T08:04:27Z

Le laboratoire "Bases Moléculaires et Structurales de Systèmes Infectieux" (BMSSI) UMR CNRS/UCBL localisé à l'Institut de Biologie et Chimie des Protéines de Lyon, lance un appel à candidature pour rechercher son directeur pour le prochain contrat quinquennal 2016-2020.

Date limite de candidature : 15 juin 2013
Prise de fonction : 1^er janvier 2016

Appel à candidature

Congrès “Drug Discovery & Therapy World Congress 2013”, 3-6 june, Boston, MA

2013-03-26T12:00:47Z

This unique international conference will provide a platform for all pharmaceutical scientists, internists and primary care physicians to discuss important international breakthroughs in drug discovery and new therapeutics. The focus of the conference will be on the interdisciplinary fields of drug discovery, drug therapy and translational medicine. For further information, please contact A. Di Pietro (BMSSI)

Plus d'informations : http://www.ddtwc.com/

Collagen Gordon Conference 2013

2013-02-15T16:16:28Z

Le programme du Gordon Conference 2013 sur "Collagen : In the Context of Matrix, Cells and Regenerative Medicine" est maintenant disponible. Le congrès aura lieu à Colby-Sawyer College, New London, NH, USA, du 14 au 19 juillet, et sera précédé par un Gordon Research Seminar, sur la même thème, organisé par des jeunes chercheurs. Pour plus d'informations, contacter David Hulmes ou visiter le site web du congrès (http://www.grc.org/programs.aspx?ye...)

News and updates

Suzana SALCEDO — 2012-12-22T16:02:56Z

in press

Martirosyan A, Pérez-Gutierrez C, Banchereau R, Dutartre H, Lecine P, Dullaers M, Mello M, Salcedo SP, Muller A, Leserman L, Levy Y, Zurawski G, Zurawski S, Moreno E, Moriyón I, Klechevsky E, Banchereau J, Oh S, Gorvel JP. Brucella β 1,2 Cyclic Glucan Is an Activator of Human and Mouse Dendritic Cells. PLoS Pathogens (in press).

Salcedo SP, Chevrier N, Lacerda TLS, Ben Amira A, Gerart S, Gorvel VA, de Chastellier C, Blasco JM, Mege JL and Gorvel JP (2012). Pathogenic Brucellae replicate in human trophoblasts. Journal of Infectious Diseases (in press).

Lacerda TLS, Salcedo SP and Gorvel JP (2012). Brucella T4SS : the VIP pass inside host cells. Current Opinion in Microbiology (in press).

CV

Suzana SALCEDO — 2012-12-22T15:09:25Z

Education

PhD in Cellular Microbiology (2003) Centre for Molecular Microbiology and Infection, Imperial College London, UK

MSc in Infectious Diseases (1999) Hammersmith Hospital, Imperial College London, UK

Four-year undergraduate degree in Microbiology (1998) Biotechnology School, Porto Catholic University, Portugal

Publications

Lacerda TLS, Salcedo SP and Gorvel JP (2012). Brucella T4SS : the VIP pass inside host cells. Current Opinion in Microbiology (in press).

Martirosyan A, Pérez-Gutierrez C, Banchereau R, Dutartre H, Lecine P, Dullaers M, Mello M, Salcedo SP, Muller A, Leserman L, Levy Y, Zurawski G, Zurawski S, Moreno E, Moriyón I, Klechevsky E, Banchereau J, Oh S, Gorvel JP. (2012) Brucella β 1,2 Cyclic Glucan Is an Activator of Human and Mouse Dendritic Cells. PLoS Pathogens ; 8 (11) : e1002983.

Marchesini MI, Herrmann CK, Salcedo SP, Gorvel JP and Comerci DJ (2011). In search of Brucella abortus Type IV secretion substrates : screening and identification of four proteins translocated into host cells through VirB system. Cellular Microbiology ; 13 (8) : 1261-74.

De Barsy M, Jamet A, Filopon D, Nicolas C, Laloux G, Rual JF, Muller A, Twizere JC, Nikegfac B, Vandenhaute J, Hill DE, Salcedo SP, Gorvel JP, Letesson JJ and de Bolle X (2011). Identification of a Brucella spp. Secreted Effector Specifically Interacting with Human Small GTPase Rab2. Cellular Microbiology ; 13 (7) : 1044-58.

Salcedo SP and Cid VJ (2011). Nontypable Haemophilus influenzae : an intracellular phase within epithelial cells might contribute to persistence. Comment in Microbiology ; 157 : 1 - 2.

Amara AB, Ghigo E, Le Priol E, Le´polard C, Salcedo SP, Lemichez E, Bretelle F, Capo C, Mege JL (2010). Coxiella burnetii, the Agent of Q Fever, Replicates within Trophoblasts and Induces a Unique Transcriptional. PlosOne, vol5, e15315.

Archambaud C, Salcedo SP, Lelouard H, Devilard E, de Bovis B, Van Rooijen N, Gorvel JP and Malissen B (2010) Contrasted role of macrophages and dendritic cells in controlling initial pulmonary Brucella infection. European Journal of Immunology. 40 (12) : 3458-71.

Lacerda TL, Cardoso PG, Augusto de Almeida L, Camargo IL, Afonso DA, Trant CC, Macedo GC, Campos E, Cravero SL, Salcedo SP, Gorvel JP, Oliveira SC (2010). Inactivation of formyltransferase (wbkC) gene generates a Brucella abortus rough strain that is attenuated in macrophages and in mice. Vaccine. (34):5627-34.

Trant CGMC, Lacerda TLS, Azevedo V, Rosinha GMS, Salcedo SP, Gorvel JP, Oliveira SC (2010). Brucella abortus phosphoglycerate kinase mutant is highly attenuated and induces superior protection than vaccine strain 19 in IRF-1 knockout and 129/Sv mice. Infection and Immunity 78 (5) : 2283-91.

Fugier E, Salcedo SP, Chastellier C, Pophillat M, Muller A, Arce-Gorvel V, Fourquet P, and Gorvel JP (2009) The glyceraldehyde-3-phosphate dehydrogenase and the small GTPase Rab 2 are crucial for Brucella replication. PLoS Pathogens 5 (6) : e1000487.

Salcedo SP, Marchesini MI, Lelouard H, Fugier E, Jolly G, Balor S, Muller A, Lapaque N, Demaria O, Alexopoulou L, Comerci DJ, Ugalde RA, Pierre P, Gorvel JP (2008) Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1. PLoS Pathogens 4 (2) : e21.

Deiwick J*, Salcedo SP*, Boucrot E, Gilliland SM, Henry T, Petermann N, Waterman SR, Gorvel JP, Holden DW, Meresse S. (2006) The translocated Salmonella effector proteins SseF and SseG interact and are required to establish an intracellular replication niche. Infection and Immunity 74 : 6965-72. *authors contributed equally to this work

Conde-Alvarez R, Grilló MJ, Salcedo SP, Miguel MJ, Fugier E, Gorvel JP, Moriyón I and Iriarte M (2006) Synthesis of phosphatidylcholine, a typical eukaryoyic phospholipid, is necessary for full virulence of the intracellular bacterial parasite Brucella abortus. Cellular Microbiology 8 : 1322-35.

Arellano-Reynoso B, Lapaque N, Salcedo S, Briones G, Ciocchini AE, Ugalde R, Moreno E, Moriyon I, Gorvel JP (2005) Cyclic beta-1,2-glucan is a Brucella virulence factor required for intracellular survival. Nature Immunology. 6 : 618-25.

Celli J, Salcedo SP and Gorvel JP (2005) Brucella coopts the small GTPase Sar1 for intracellular replication PNAS 102 : 1673-1679.

Salcedo SP and Holden DW. (2003) SseG, a virulence protein that targets Salmonella to the Golgi network. EMBO Journal 22 : 5003-5014.

Beuzón CR, Salcedo SP and Holden DW. (2002) Growth and killing of a Salmonella enterica serovar Typhimurium sifA mutant strain in the cytosol of different host cell lines. Microbiology 148 : 2705-2715.

Salcedo SP, Noursadeghi M, Cohen J and Holden DW. (2001) Intracellular replication of Salmonella typhimurium strains in specific subsets of splenic macrophages in vivo. Cellular Microbiology 3 : 587-597.

Reviews and book chapters

Von Bargen K, Gorvel JP and Salcedo SP (2012). Internal affairs : investigating the Brucella intracellular lifestyle. FEMS Microbiology Reviews ; 36 (3) : 533-62.

Salcedo SP and Gorvel JP (2009). Brucella, a perfect Trojan horse in phagocytes. 427-435 in Phagocyte-Pathogen interactions. Editors : Russell DG and Gordon S. ASM Press.

Roy CR, Salcedo SP and Gorvel JP (2006) Pathogen–endoplasmic-reticulum interactions : in through the out door. Nature Reviews Immunology 6 : 136-47.

Salcedo SP and Holden DW. (2005) Bacterial interactions with the secretory pathway. Current Opinion in Microbiology 8 : 92-98.

Financement

Suzana SALCEDO — 2012-12-21T10:30:37Z

FINOVI Young Investigator Team Leader contract (2012-2016) : Studying bacteria-host interactions in nosocomilas : Acinetobacter baumannii as a model system.

ERA-NET PathoGenoMics (2011-2014) ; ANR CELLPATH : Characterisation of host cell pathways altered by effectors of Brucella, Chlamydia, and Coxiella

presentation

Suzana SALCEDO — 2012-12-18T13:22:05Z

Our group is interested in studying bacterial-host interactions, with particular emphasis on the role of bacterial proteins that promote virulence. These proteins may be modifying host cellular pathways to aid replication, allow the pathogen to subvert the immune response or enabling persistence within the host and abiotic surfaces in a hospital setting.

We are actively characterising and comparing TIR-containing proteins from a select group of bacterial pathogens. The Toll/Interleukin-1 receptor (TIR) domain is a conserved intracellular domain present on TLR receptors, and is shared by the downstream adaptor molecules. TLRs recognize pathogen-associated molecular patterns (PAMPs) and are essential for TLR signaling and innate immunity. Bacterial TIR effectors have been implicated in the virulence of Brucella spp., Salmonella spp. and uropathogenic E. coli highlighting their relevance in disease progression.

We also have an ongoing ERA-Net Pathogenomics/ANR project to characterise novel effector proteins exported into host cells by the intracellular pathogen Brucella and identify the cellular signalling pathways targeted during infection. This project is part of a larger consortium that aims at identifying unique pathways that may be used for innovative therapeutic approaches to control the intracellular pathogens Coxiella, Chlamydia and Brucella.

We are now starting a project to study Acinetobacter baumannii, an emerging nosocomial pathogen that can cause severe infections in compromised patients and is becoming a health problem worldwide. A. baumannii are highly resistant to antibiotics and are implicated in a variety of infections such as respiratory tract, bloodstream, urinary tract, skin and soft tissue and prosthetic devices. By characterising its interaction with human cells and identifying virulence determinants that can promote disease in susceptible hosts we hope to propose new strategies to combat A. baumannii that may be applicable to other multi-drug resistant Gram-negative nosocomials.

http://perso.ibcp.fr/suzana.salcedo/

Lancement de Laboratoire International Associé

Gilbert DELEAGE — 2012-11-13T09:06:11Z

L'équipe animée par A. Bockmann et F.Penin est partenaire d'un LIA CNRS (Laboratoire International Associé) porté par C. Chipot (Laboratoire Struc ture et Réactivité des Systèmes Moléculaires Complexes CNRS/Université de Lorraine, France) et Klaus Schulten (Université de l'Illinois Urbana-Champaign, Etats-Unis) et qui réunit plusieurs autres équipes Françaises. La thématique du LIA porte sur l'Apport de réponses inédites à des problèmes biologiques complexes grâce aux simulations numériques hautes performances. Le lancement a eu lieu les 5 et 6 octobre 2012 à Nancy en présence de Frank Pattus en charge de l'International à l'INSB.

Voir le communiqué de presse de l'AEF.

test fr

Alexis MICHON — 2012-10-04T10:38:13Z

je suis en francais - Biologie structurale des complexes macromoléculaires bactériens (L Terradot)