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Publications
135. The acid tolerant and cold-active ?-galactosidase from Lactococcus lactis strain is an attractive biocatalyst for lactose hydrolysis.
Vincent V, Aghajari N, Pollet N, Boisson A, Boudebbouze S, Haser R, Maguin E, Rhimi M
(2013) Antonie Van Leeuwenhoek 103 : 701-12
134. Quantitative evaluation of the combination between cytotoxic drug and efflux transporter inhibitors based on a tumour growth inhibition model.
Sostelly A, Payen L, Guitton J, Pietro AD, Falson P, Honorat M, Boumendjel A, Geze A, Freyer G, Tod M
(2013) Fundam Clin Pharmacol :
133. Mutations inducing an active-site aperture in Rhizobium sp. sucrose isomerase confer hydrolytic activity.
Lipski A, Watzlawick H, Ravaud S, Robert X, Rhimi M, Haser R, Mattes R, Aghajari N
(2013) Acta Crystallogr D Biol Crystallogr 69 : 298-307
132. Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2[prime]-deoxyuridine-5[prime]-monophosphate on ABCC11 in silico models.
Honorat M, Terreux R, Falson P, Di Pietro A, Dumontet C, Payen L
(2013) BMC Struct Biol 13 : 7-7
131. Identification and characterization of inhibitors of cytoplasmic 5'-nucleotidase cN-II issued from virtual screening.
Jordheim LP, Marton Z, Rhimi M, Cros-Perrial E, Lionne C, Peyrottes S, Dumontet C, Aghajari N, Chaloin L
(2013) Biochem Pharmacol 85 : 497-506
130. Regulatory Interactions between a Bacterial Tyrosine Kinase and its Cognate Phosphatase.
Temel DB, Dutta K, Alphonse S, Nourikyan J, Grangeasse C, Ghose R
(2013) J Biol Chem :
129. Azaindole derivatives are inhibitors of microtubule dynamics, with anti-cancer and anti-angiogenic activities.
Prudent R, Vassal-Stermann E, Nguyen CH, Mollaret M, Viallet J, Desroches-Castan A, Martinez A, Barette C, Pillet C, Valdameri G, Soleilhac E, Di Pietro A, Feige JJ, Billaud M, Florent JC, Lafanechere L
(2013) Br J Pharmacol 168 : 673-85
2012 [Top] 13
128. A synthetic chalcone as a potent inducer of glutathione biosynthesis.
Kachadourian R, Day BJ, Pugazhenti S, Franklin CC, Genoux-Bastide E, Mahaffey G, Gauthier C, Di Pietro A, Boumendjel A
(2012) J Med Chem 55 : 1382-8
127. Methoxy stilbenes as potent, specific, untransported, and noncytotoxic inhibitors of breast cancer resistance protein.
Valdameri G, Pereira Rangel L, Spatafora C, Guitton J, Gauthier C, Arnaud O, Ferreira-Pereira A, Falson P, Winnischofer SM, Rocha ME, Tringali C, Di Pietro A
(2012) ACS Chem Biol 7 : 322-30
126. 6-halogenochromones bearing tryptamine: one-step access to potent and highly selective inhibitors of breast cancer resistance protein.
Valdameri G, Genoux-Bastide E, Gauthier C, Peres B, Terreux R, Winnischofer SM, Rocha ME, Di Pietro A, Boumendjel A
(2012) ChemMedChem 7 : 1177-80
125. Blocking human enterovirus 71 replication by targeting viral 2A protease.
Falah N, Montserret R, Lelogeais V, Schuffenecker I, Lina B, Cortay JC, Violot S
(2012) J Antimicrob Chemother 67 : 2865-9
124. Phosphorylation of CpgA protein enhances both its GTPase activity and its affinity for ribosome and is crucial for Bacillus subtilis growth and morphology.
Pompeo F, Freton C, Wicker-Planquart C, Grangeasse C, Jault JM, Galinier A
(2012) J Biol Chem 287 : 20830-8
123. Ex vivo and in vivo inhibition of human rhinovirus replication by a new pseudosubstrate of viral 2A protease.
Falah N, Violot S, Decimo D, Berri F, Foucault-Grunenwald ML, Ohlmann T, Schuffenecker I, Morfin F, Lina B, Riteau B, Cortay JC
(2012) J Virol 86 : 691-704
122. Stoichiometry of the MexA-OprM binding, as investigated by blue native gel electrophoresis.
Ferrandez Y, Monlezun L, Phan G, Benabdelhak H, Benas P, Ulryck N, Falson P, Ducruix A, Picard M, Broutin I
(2012) Electrophoresis 33 : 1282-7
121. Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity.
Valdameri G, Gauthier C, Terreux R, Kachadourian R, Day BJ, Winnischofer SM, Rocha ME, Frachet V, Ronot X, Di Pietro A, Boumendjel A
(2012) J Med Chem 55 : 3193-200
120. Bridging the gap between structure and kinetics of human SGLT1.
Sala-Rabanal M, Hirayama BA, Loo DD, Chaptal V, Abramson J, Wright EM
(2012) Am J Physiol Cell Physiol 302 : C1293-305
119. A template model for studying anticancer drug efflux transporter inhibitors in vitro.
Sostelly A, Payen L, Guitton J, Pietro AD, Falson P, Honorat M, Valdameri G, Geze A, Boumendjel A, Freyer G, Tod M
(2012) Fundam Clin Pharmacol :
118. Substituted chromones as highly potent nontoxic inhibitors, specific for the breast cancer resistance protein.
Valdameri G, Genoux-Bastide E, Peres B, Gauthier C, Guitton J, Terreux R, Winnischofer SM, Rocha ME, Boumendjel A, Di Pietro A
(2012) J Med Chem 55 : 966-70
117. Microparticle-mediated transfer of the viral receptors CAR and CD46, and the CFTR channel in a CHO cell model confers new functions to target cells.
Gonzalez G, Vituret C, Di Pietro A, Chanson M, Boulanger P, Hong SS
(2012) PLoS One 7 : e52326-e52326
116. Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth.
Prudent R, Vassal-Stermann E, Nguyen CH, Pillet C, Martinez A, Prunier C, Barette C, Soleilhac E, Filhol O, Beghin A, Valdameri G, Honore S, Aci-Seche S, Grierson D, Antonipillai J, Li R, Di Pietro A, Dumontet C, Braguer D, Florent JC, Knapp S, Bernard O, Lafanechere L
(2012) Cancer Res 72 : 4429-39
2011 [Top] 12
115. Leucine-rich protein 130 contributes to apoptosis resistance of human hepatocarcinoma cells.
Michaud M, Barakat S, Magnard S, Rigal D, Baggetto LG
(2011) Int J Oncol 38 : 169-78
114. MRP8/ABCC11 expression is regulated by dexamethasone in breast cancer cells and is associated to progesterone receptor status in breast tumors.
Honorat M, Mesnier A, Vendrell J, Di Pietro A, Lin V, Dumontet C, Cohen P, Payen L
(2011) Int J Breast Cancer 2011 : 807380-807380
113. Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition.
Chaptal V, Kwon S, Sawaya MR, Guan L, Kaback HR, Abramson J
(2011) Proc Natl Acad Sci U S A 108 : 9361-6
112. Supramolecular stabilization of acid tolerant L-arabinose isomerase from Lactobacillus sakei.
Jebors S, Tauran Y, Aghajari N, Boudebbouze S, Maguin E, Haser R, Coleman AW, Rhimi M
(2011) Chem Commun (Camb) 47 : 12307-9
111. Targeting the multidrug ABCG2 transporter with flavonoidic inhibitors: in vitro optimization and in vivo validation.
Boumendjel A, Macalou S, Valdameri G, Pozza A, Gauthier C, Arnaud O, Nicolle E, Magnard S, Falson P, Terreux R, Carrupt PA, Payen L, Di Pietro A
(2011) Curr Med Chem 18 : 3387-401
110. Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells.
Selever J, Gu G, Lewis MT, Beyer A, Herynk MH, Covington KR, Tsimelzon A, Dontu G, Provost P, Di Pietro A, Boumendjel A, Albain K, Miele L, Weiss H, Barone I, Ando S, Fuqua SA
(2011) Clin Cancer Res 17 : 6510-21
109. The acridone derivative MBLI-87 sensitizes breast cancer resistance protein-expressing xenografts to irinotecan.
Arnaud O, Boumendjel A, Geze A, Honorat M, Matera EL, Guitton J, Stein WD, Bates SE, Falson P, Dumontet C, Di Pietro A, Payen L
(2011) Eur J Cancer 47 : 640-8
108. The acid-tolerant L-arabinose isomerase from the mesophilic Shewanella sp. ANA-3 is highly active at low temperatures.
Rhimi M, Bajic G, Ilhammami R, Boudebbouze S, Maguin E, Haser R, Aghajari N
(2011) Microb Cell Fact 10 : 96-96
107. Identification of xanthones as selective killers of cancer cells overexpressing the ABC transporter MRP1.
Genoux-Bastide E, Lorendeau D, Nicolle E, Yahiaoui S, Magnard S, Di Pietro A, Baubichon-Cortay H, Boumendjel A
(2011) ChemMedChem 6 : 1478-84
106. Structuring detergents for extracting and stabilizing functional membrane proteins.
Matar-Merheb R, Rhimi M, Leydier A, Huche F, Galian C, Desuzinges-Mandon E, Ficheux D, Flot D, Aghajari N, Kahn R, Di Pietro A, Jault JM, Coleman AW, Falson P
(2011) PLoS One 6 : e18036-e18036
105. Production of D-tagatose, a low caloric sweetener during milk fermentation using L-arabinose isomerase
Rhimi M, Chouayekh H, Gouillouard I, Maguin E, Bejar S
(2011) BIORESOURCE TECHNOLOGY 102 : 3309-3315
104. Multidrug resistance ABC transporter structure predictions by homology modeling approaches.
Honorat M, Falson P, Terreux R, Di Pietro A, Dumontet C, Payen L
(2011) Curr Drug Metab 12 : 268-77
2010 [Top] 10
103. Iodination of verapamil for a stronger induction of death, through GSH efflux, of cancer cells overexpressing MRP1.
Barattin R, Perrotton T, Trompier D, Lorendeau D, Di Pietro A, D'Hardemare Adu M, Baubichon-Cortay H
(2010) Bioorg Med Chem 18 : 6265-74
102. Efficient bioconversion of lactose in milk and whey: immobilization and biochemical characterization of a beta-galactosidase from the dairy Streptococcus thermophilus LMD9 strain.
Rhimi M, Boisson A, Dejob M, Boudebouze S, Maguin E, Haser R, Aghajari N
(2010) Res Microbiol 161 : 515-25
101. The multidrug resistance half-transporter ABCG2 is purified as a tetramer upon selective extraction from membranes.
Dezi M, Fribourg PF, Di Cicco A, Arnaud O, Marco S, Falson P, Di Pietro A, Levy D
(2010) Biochim Biophys Acta 1798 : 2094-101
100. Potent and fully noncompetitive peptidomimetic inhibitor of multidrug resistance P-glycoprotein.
Arnaud O, Koubeissi A, Ettouati L, Terreux R, Alame G, Grenot C, Dumontet C, Di Pietro A, Paris J, Falson P
(2010) J Med Chem 53 : 6720-9
99. Magnesium dependent complexation of tri-anionic calix[4]arene detergents by the nucleotide binding domain 1 (NBD1) of multidrug resistance protein MRP1
Nault LFA, Girardot C, Leydier A, Coleman AW, Perrotton T, Magnard S, Baubichon-Cortay H
(2010) NEW JOURNAL OF CHEMISTRY 34 : 1812-1815
98. Mammalian membrane protein expression in baculovirus-infected insect cells.
Trometer C, Falson P
(2010) Methods Mol Biol 601 : 105-17
97. Insect cell versus bacterial overexpressed membrane proteins: an example, the human ABCG2 transporter.
Pozza A, Perez-Victoria JM, Di Pietro A
(2010) Methods Mol Biol 654 : 47-75
96. The acid tolerant L-arabinose isomerase from the food grade Lactobacillus sakei 23K is an attractive D-tagatose producer.
Rhimi M, Ilhammami R, Bajic G, Boudebbouze S, Maguin E, Haser R, Aghajari N
(2010) Bioresour Technol 101 : 9171-7
95. ABCG2 transports and transfers heme to albumin through its large extracellular loop.
Desuzinges-Mandon E, Arnaud O, Martinez L, Huche F, Di Pietro A, Falson P
(2010) J Biol Chem 285 : 33123-33
94. Multiple effects of silymarin on the hepatitis C virus lifecycle.
Wagoner J, Negash A, Kane OJ, Martinez LE, Nahmias Y, Bourne N, Owen DM, Grove J, Brimacombe C, McKeating JA, Pecheur EI, Graf TN, Oberlies NH, Lohmann V, Cao F, Tavis JE, Polyak SJ
(2010) Hepatology 51 : 1912-21
2009 [Top] 11
93. Exploring the acidotolerance of beta-galactosidase from Lactobacillus delbrueckii subsp. bulgaricus: an attractive enzyme for lactose bioconversion.
Rhimi M, Aghajari N, Jaouadi B, Juy M, Boudebbouze S, Maguin E, Haser R, Bejar S
(2009) Res Microbiol 160 : 775-84
92. A 3D linear solvation energy model to quantify the affinity of flavonoid derivatives toward P-glycoprotein.
Boccard J, Bajot F, Di Pietro A, Rudaz S, Boumendjel A, Nicolle E, Carrupt PA
(2009) Eur J Pharm Sci 36 : 254-64
91. Rational design of Bacillus stearothermophilus US100 L-arabinose isomerase: potential applications for D-tagatose production.
Rhimi M, Aghajari N, Juy M, Chouayekh H, Maguin E, Haser R, Bejar S
(2009) Biochimie 91 : 650-3
90. Breast cancer resistance protein (BCRP/ABCG2): new inhibitors and QSAR studies by a 3D linear solvation energy approach.
Nicolle E, Boccard J, Guilet D, Dijoux-Franca MG, Zelefac F, Macalou S, Grosselin J, Schmidt J, Carrupt PA, Di Pietro A, Boumendjel A
(2009) Eur J Pharm Sci 38 : 39-46
89. Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells.
Robey RW, Obrzut T, Shukla S, Polgar O, Macalou S, Bahr JC, Di Pietro A, Ambudkar SV, Bates SE
(2009) Cancer Chemother Pharmacol 64 : 575-83
88. Jatrophane diterpenes from Euphorbia spp. as modulators of multidrug resistance in cancer therapy
Corea G, Di Pietro A, Dumontet C, Fattorusso E, Lanzotti V
(2009) PHYTOCHEMISTRY REVIEWS 8 : 431-447
87. Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla.
Nguyen VT, Darbour N, Bayet C, Doreau A, Raad I, Phung BH, Dumontet C, Di Pietro A, Dijoux-Franca MG, Guilet D
(2009) Fitoterapia 80 : 39-42
86. Overexpression of homogeneous and active ABCG2 in insect cells.
Pozza A, Perez-Victoria JM, Prez-Victoria JM, Di Pietro A
(2009) Protein Expr Purif 63 : 75-83
85. Involvement of cysteine 306 and alanine 63 in the thermostability and oligomeric organization of glucose isomerase from Streptomyces sp SK
Borgi MA, Rhimi M, Aghajari N, Ben Ali M, Juy M, Haser R, Bejar S
(2009) BIOLOGIA 64 : 845-851
84. Probing the conformation of the resting state of a bacterial multidrug ABC transporter, BmrA, by a site-directed spin labeling approach.
Do Cao MA, Crouzy S, Kim M, Becchi M, Cafiso DS, Di Pietro A, Jault JM
(2009) Protein Sci 18 : 1507-20
83. QSAR analysis and molecular modeling of ABCG2-specific inhibitors.
Nicolle E, Boumendjel A, Macalou S, Genoux E, Ahmed-Belkacem A, Carrupt PA, Di Pietro A
(2009) Adv Drug Deliv Rev 61 : 34-46
2008 [Top] 6
82. Conformational change induced by ATP binding in the multidrug ATP-binding cassette transporter BmrA.
Orelle C, Gubellini F, Durand A, Marco S, Levy D, Gros P, Di Pietro A, Jault JM
(2008) Biochemistry 47 : 2404-12
81. Bacterial sucrose isomerases: properties and structural studies
Rhimi M, Haser R, Aghajari N
(2008) BIOLOGIA 63 : 1020-1027
80. Discovery of a new series of jatrophane and lathyrane diterpenes as potent and specific P-glycoprotein modulators.
Barile E, Borriello M, Di Pietro A, Doreau A, Fattorusso C, Fattorusso E, Lanzotti V
(2008) Org Biomol Chem 6 : 1756-62
79. Dexamethasone down-regulates ABCG2 expression levels in breast cancer cells.
Honorat M, Mesnier A, Di Pietro A, Lin V, Cohen P, Dumontet C, Payen L
(2008) Biochem Biophys Res Commun 375 : 308-14
78. Trianionic calix[4]arene monoalkoxy derivatives: synthesis, solid-state structures and self-assembly properties
Suwinska K, Shkurenko O, Mbemba C, Leydier A, Jebors S, Coleman AW, Matar R, Falson P
(2008) NEW JOURNAL OF CHEMISTRY 32 : 1988-1998
77. Biochemical and molecular characterization of a detergent-stable serine alkaline protease from Bacillus pumilus CBS with high catalytic efficiency
Jaouadi B , Ellouz-Chaabouni S , Rhimi M , Bejar S
(2008) BIOCHIMIE 90 : 1291-1305
2007 [Top] 6
76. Probing the essential catalytic residues and substrate affinity in the thermoactive Bacillus stearothermophilus US100 L-arabinose isomerase by site-directed mutagenesis.
Rhimi M, Juy M, Aghajari N, Haser R, Bejar S
(2007) J Bacteriol 189 : 3556-63
75. Nonprenylated rotenoids, a new class of potent breast cancer resistance protein inhibitors.
Ahmed-Belkacem A, Macalou S, Borrelli F, Capasso R, Fattorusso E, Taglialatela-Scafati O, Di Pietro A
(2007) J Med Chem 50 : 1933-8
74. Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2.
Boumendjel A, Macalou S, Ahmed-Belkacem A, Blanc M, Di Pietro A
(2007) Bioorg Med Chem 15 : 2892-7
73. Influence of tyrosine-kinase Wzc activity on colanic acid production in Escherichia coli K12 cells.
Obadia B, Lacour S, Doublet P, Baubichon-Cortay H, Cozzone AJ, Grangeasse C
(2007) J Mol Biol 367 : 42-53
72. Tyrosine-kinase Wzc from Escherichia coli possesses an ATPase activity regulated by autophosphorylation.
Soulat D, Jault JM, Geourjon C, Gouet P, Cozzone AJ, Grangeasse C
(2007) FEMS Microbiol Lett 274 : 252-9
71. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1.
Perrotton T, Trompier D, Chang XB, Di Pietro A, Baubichon-Cortay H
(2007) J Biol Chem 282 : 31542-8
2006 [Top] 7
70. Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux.
Perez-Victoria JM, Cortes-Selva F, Parodi-Talice A, Bavchvarov BI, Perez-Victoria FJ, Munoz-Martinez F, Maitrejean M, Costi MP, Barron D, Di Pietro A, Castanys S, Gamarro F
(2006) Antimicrob Agents Chemother 50 : 3102-10
69. Purification of breast cancer resistance protein ABCG2 and role of arginine-482
Pozza A, Perez-Victoria JM, Sardo A, Ahmed-Belkacem A, Di Pietro A
(2006) CELLULAR AND MOLECULAR LIFE SCIENCES 63 : 1912-1922
68. Conformational changes in sarcoplasmic reticulum Ca(2+)-ATPase mutants: effect of mutations either at Ca(2+)-binding site II or at tryptophan 552 in the cytosolic domain.
Lenoir G, Jaxel C, Picard M, Le Maire M, Champeil P, Falson P
(2006) Biochemistry 45 : 5261-70
67. Role of the yeast ABC transporter Yor1p in cadmium detoxification.
Nagy Z, Montigny C, Leverrier P, Yeh S, Goffeau A, Garrigos M, Falson P
(2006) Biochimie 88 : 1665-71
66. The ABC transporter BmrA from Bacillus subtilis is a functional dimer when in a detergent-solubilized state.
Ravaud S, Do Cao MA, Jidenko M, Ebel C, Le Maire M, Jault JM, Di Pietro A, Haser R, Aghajari N
(2006) Biochem J 395 : 345-53
65. Staphylococcus aureus operates protein-tyrosine phosphorylation through a specific mechanism.
Soulat D, Jault JM, Duclos B, Geourjon C, Cozzone AJ, Grangeasse C
(2006) J Biol Chem 281 : 14048-56
64. Inhibitors of cancer cell multidrug resistance mediated by breast cancer resistance protein (BCRP/ABCG2).
Ahmed-Belkacem A, Pozza A, Macalou S, Perez-Victoria JM, Boumendjel A, Di Pietro A
(2006) Anticancer Drugs 17 : 239-43
2005 [Top] 4
63. Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.
Ahmed-Belkacem A, Pozza A, Munoz-Martinez F, Bates SE, Castanys S, Gamarro F, Di Pietro A, Perez-Victoria JM
(2005) Cancer Res 65 : 4852-60
62. The Q-loop disengages from the first intracellular loop during the catalytic cycle of the multidrug ABC transporter BmrA.
Dalmas O, Orelle C, Foucher AE, Geourjon C, Crouzy S, Di Pietro A, Jault JM
(2005) J Biol Chem 280 : 36857-64
61. Time-resolved fluorescence resonance energy transfer shows that the bacterial multidrug ABC half-transporter BmrA functions as a homodimer.
Dalmas O, Do Cao MA, Lugo MR, Sharom FJ, Di Pietro A, Jault JM
(2005) Biochemistry 44 : 4312-21
60. Anticancer multidrug resistance mediated by MRP1: recent advances in the discovery of reversal agents.
Boumendjel A, Baubichon-Cortay H, Trompier D, Perrotton T, Di Pietro A
(2005) Med Res Rev 25 : 453-72
2004 [Top] 6
59. Structure-activity relationships for euphocharacins A-L, a new series of jatrophane diterpenes, as inhibitors of cancer cell P-glycoprotein.
Corea G, Fattorusso E, Lanzotti V, Motti R, Simon PN, Dumontet C, Di Pietro A
(2004) Planta Med 70 : 657-65
58. Structural insight into the cooperativity between catalytic and noncatalytic sites of F1-ATPase.
Falson P, Goffeau A, Boutry M, Jault JM
(2004) Biochim Biophys Acta 1658 : 133-40
57. Characterization of YvcC (BmrA), a multidrug ABC transporter constitutively expressed in Bacillus subtilis.
Steinfels E, Orelle C, Fantino JR, Dalmas O, Rigaud JL, Denizot F, Di Pietro A, Jault JM
(2004) Biochemistry 43 : 7491-502
56. Jatrophane diterpenes as modulators of multidrug resistance. Advances of structure-activity relationships and discovery of the potent lead pepluanin A.
Corea G, Fattorusso E, Lanzotti V, Motti R, Simon PN, Dumontet C, Di Pietro A
(2004) J Med Chem 47 : 988-92
55. Verapamil and its derivative trigger apoptosis through glutathione extrusion by multidrug resistance protein MRP1.
Trompier D, Chang XB, Barattin R, Du Moulinet D'Hardemare A, Di Pietro A, Baubichon-Cortay H
(2004) Cancer Res 64 : 4950-6
54. Two FHA domains on an ABC transporter, Rv1747, mediate its phosphorylation by PknF, a Ser/Thr protein kinase from Mycobacterium tuberculosis.
Molle V, Soulat D, Jault JM, Grangeasse C, Cozzone AJ, Prost JF
(2004) FEMS Microbiol Lett 234 : 215-23
2003 [Top] 8
53. The conserved glutamate residue adjacent to the Walker-B motif is the catalytic base for ATP hydrolysis in the ATP-binding cassette transporter BmrA.
Orelle C, Dalmas O, Gros P, Di Pietro A, Jault JM
(2003) J Biol Chem 278 : 47002-8
52. Modified jatrophane diterpenes as modulators of multidrug resistance from Euphorbia dendroides L.
Corea G, Fattorusso E, Lanzotti V, Taglialatela-Scafati O, Appendino G, Ballero M, Simon PN, Dumontet C, Di Pietro A
(2003) Bioorg Med Chem 11 : 5221-7
51. A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).
Appendino G, Della Porta C, Conseil G, Sterner O, Mercalli E, Dumontet C, Di Pietro A
(2003) J Nat Prod 66 : 140-2
50. Regulation and mutational analysis of the HPr kinase/phosphorylase from Bacillus subtilis.
Pompeo F, Granet Y, Lavergne JP, Grangeasse C, Nessler S, Jault JM, Galinier A
(2003) Biochemistry 42 : 6762-71
49. Multiple flavonoid-binding sites within multidrug resistance protein MRP1.
Trompier D, Baubichon-Cortay H, Chang XB, Maitrejean M, Barron D, Riordon JR, Di Pietro A
(2003) Cell Mol Life Sci 60 : 2164-77
48. Potent competitive inhibition of drug binding to the Saccharomyces cerevisiae ABC exporter Pdr5p by the hydrophobic estradiol-derivative RU49953.
Conseil G, Perez-Victoria JM, Renoir JM, Goffeau A, Di Pietro A
(2003) Biochim Biophys Acta 1614 : 131-4
47. RU49953: a non-hormonal steroid derivative that potently inhibits P-glycoprotein and reverts cellular multidrug resistance.
Perez-Victorias FJ, Conseil G, Munoz-Martinez F, Perez-Victoria JM, Dayan G, Marsaud V, Castanys S, Gamarro F, Renoir JM, Di Pietro A
(2003) Cell Mol Life Sci 60 : 526-35
46. Jatrophane diterpenes as P-glycoprotein inhibitors. First insights of structure-activity relationships and discovery of a new, powerful lead.
Corea G, Fattorusso E, Lanzotti V, Taglialatela-Scafati O, Appendino G, Ballero M, Simon PN, Dumontet C, Di Pietro A
(2003) J Med Chem 46 : 3395-402
2002 [Top] 9
45. Insights into the functioning of Bacillus subtilis HPr kinase/phosphatase: affinity for its protein substrates and role of cations and phosphate.
Lavergne JP, Jault JM, Galinier A
(2002) Biochemistry 41 : 6218-25
44. Highly efficient over-production in E. coli of YvcC, a multidrug-like ATP-binding cassette transporter from Bacillus subtilis.
Steinfels E, Orelle C, Dalmas O, Penin F, Miroux B, Di Pietro A, Jault JM
(2002) Biochim Biophys Acta 1565 : 1-5
43. 4-Hydroxy-6-methoxyaurones with high-affinity binding to cytosolic domain of P-glycoprotein.
Boumendjel A, Beney C, Deka N, Mariotte AM, Lawson MA, Trompier D, Baubichon-Cortay H, Di Pietro A
(2002) Chem Pharm Bull (Tokyo) 50 : 854-6
42. Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance.
Boumendjel A, Di Pietro A, Dumontet C, Barron D
(2002) Med Res Rev 22 : 512-29
41. Interaction between the antiapoptotic protein Nr-13 and cytochrome c. Antagonistic effect of the BH3 domain of Bax.
Moradi-Ameli M, Lorca T, Ficheux D, Di Pietro A, Gillet G
(2002) Biochemistry 41 : 8540-50
40. A new family of phosphotransferases with a P-loop motif.
Galinier A, Lavergne JP, Geourjon C, Fieulaine S, Nessler S, Jault JM
(2002) J Biol Chem 277 : 11362-7
39. Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters.
Di Pietro A, Conseil G, Perez-Victoria JM, Dayan G, Baubichon-Cortay H, Trompier D, Steinfels E, Jault JM, De Wet H, Maitrejean M, Comte G, Boumendjel A, Mariotte AM, Dumontet C, McIntosh DB, Goffeau A, Castanys S, Gamarro F, Barron D
(2002) Cell Mol Life Sci 59 : 307-22
38. Three-dimensional structure by cryo-electron microscopy of YvcC, an homodimeric ATP-binding cassette transporter from Bacillus subtilis.
Chami M, Steinfels E, Orelle C, Jault JM, Di Pietro A, Rigaud JL, Marco S
(2002) J Mol Biol 315 : 1075-85
37. Multidrug resistance phenotype mediated by the P-glycoprotein-like transporter in Leishmania: a search for reversal agents.
Perez-Victoria JM, Di Pietro A, Barron D, Ravelo AG, Castanys S, Gamarro F
(2002) Curr Drug Targets 3 : 311-33
2001 [Top] 10
36. B-ring substituted 5,7-dihydroxyflavonols with high-affinity binding to P-glycoprotein responsible for cell multidrug resistance.
Boumendjel A, Bois F, Beney C, Mariotte AM, Conseil G, Di Pietro A
(2001) Bioorg Med Chem Lett 11 : 75-7
35. High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin.
Perez-Victoria JM, Perez-Victoria FJ, Conseil G, Maitrejean M, Comte G, Barron D, Di Pietro A, Castanys S, Gamarro F
(2001) Antimicrob Agents Chemother 45 : 439-46
34. Protein kinase C effectors bind to multidrug ABC transporters and inhibit their activity.
Conseil G, Perez-Victoria JM, Jault JM, Gamarro F, Goffeau A, Hofmann J, Di Pietro A
(2001) Biochemistry 40 : 2564-71
33. Modulation of cancer cell multidrug resistance by an extract of Ficus citrifolia.
Simon PN, Chaboud A, Darbour N, Di Pietro A, Dumontet C, Lurel F, Raynaud J, Barron D
(2001) Anticancer Res 21 : 1023-7
32. The "catalytic" triad of isocitrate dehydrogenase kinase/phosphatase from E. coli and its relationship with that found in eukaryotic protein kinases.
Oudot C, Cortay JC, Blanchet C, Laporte DC, Di Pietro A, Cozzone AJ, Jault JM
(2001) Biochemistry 40 : 3047-55
31. A common mechanism for ATP hydrolysis in ABC transporter and helicase superfamilies.
Geourjon C, Orelle C, Steinfels E, Blanchet C, Deleage G, Di Pietro A, Jault JM
(2001) Trends Biochem Sci 26 : 539-44
30. MDR1 causes resistance to the antitumour drug miltefosine.
Rybczynska M, Liu R, Lu P, Sharom FJ, Steinfels E, Pietro AD, Spitaler M, Grunicke H, Hofmann J
(2001) Br J Cancer 84 : 1405-11
29. Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein: structure-activity relationships for flavonoid binding.
De Wet H, McIntosh DB, Conseil G, Baubichon-Cortay H, Krell T, Jault JM, Daskiewicz JB, Barron D, Di Pietro A
(2001) Biochemistry 40 : 10382-91
28. Natural and synthetic benzophenones: interaction with the cytosolic binding domain of P-glycoprotein.
Rancon S, Chaboud A, Darbour N, Comte G, Bayet C, Simon PN, Raynaud J, Di Pietro A, Cabalion P, Barron D
(2001) Phytochemistry 57 : 553-7
27. C-Isoprenylation of flavonoids enhances binding affinity toward P-glycoprotein and modulation of cancer cell chemoresistance.
Comte G, Daskiewicz JB, Bayet C, Conseil G, Viornery-Vanier A, Dumontet C, Di Pietro A, Barron D
(2001) J Med Chem 44 : 763-8
2000 [Top] 5
26. The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein.
Maitrejean M, Comte G, Barron D, El Kirat K, Conseil G, Di Pietro A
(2000) Bioorg Med Chem Lett 10 : 157-60
25. Prenylated xanthones as potential P-glycoprotein modulators.
Tchamo DN, Dijoux-Franca MG, Mariotte AM, Tsamo E, Daskiewicz JB, Bayet C, Barron D, Conseil G, Di Pietro A
(2000) Bioorg Med Chem Lett 10 : 1343-5
24. Evidence for a second nucleotide binding site in rat elongation factor eEF-2 specific for adenylic nucleotides.
Gonzalo P, Sontag B, Lavergne JP, Jault JM, Reboud JP
(2000) Biochemistry 39 : 13558-64
23. Prenyl-flavonoids as potent inhibitors of the Pdr5p multidrug ABC transporter from Saccharomyces cerevisiae.
Conseil G, Decottignies A, Jault JM, Comte G, Barron D, Goffeau A, Di Pietro A
(2000) Biochemistry 39 : 6910-7
22. The HPr kinase from Bacillus subtilis is a homo-oligomeric enzyme which exhibits strong positive cooperativity for nucleotide and fructose 1,6-bisphosphate binding.
Jault JM, Fieulaine S, Nessler S, Gonzalo P, Di Pietro A, Deutscher J, Galinier A
(2000) J Biol Chem 275 : 1773-80
1999 [Top] 3
21. P-glycoprotein-mediated resistance to chemotherapy in cancer cells: using recombinant cytosolic domains to establish structure-function relationships.
Di Pietro A, Dayan G, Conseil G, Steinfels E, Krell T, Trompier D, Baubichon-Cortay H, Jault J
(1999) Braz J Med Biol Res 32 : 925-39
20. Correlation between the affinity of flavonoids binding to the cytosolic site of Leishmania tropica multidrug transporter and their efficiency to revert parasite resistance to daunomycin.
Perez-Victoria JM, Chiquero MJ, Conseil G, Dayan G, Di Pietro A, Barron D, Castanys S, Gamarro F
(1999) Biochemistry 38 : 1736-43
19. The isocitrate dehydrogenase kinase/phosphatase from Escherichia coli is highly sensitive to in-vitro oxidative conditions role of cysteine67 and cysteine108 in the formation of a disulfide-bonded homodimer.
Oudot C, Jaquinod M, Cortay JC, Cozzone AJ, Jault JM
(1999) Eur J Biochem 262 : 224-9
1998 [Top] 3
18. Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein.
Conseil G, Baubichon-Cortay H, Dayan G, Jault JM, Barron D, Di Pietro A
(1998) Proc Natl Acad Sci U S A 95 : 9831-6
17. Mutagenesis of the fructose-6-phosphate-binding site in the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
Bertrand L, Vertommen D, Freeman PM, Wouters J, Depiereux E, Di Pietro A, Hue L, Rider MH
(1998) Eur J Biochem 254 : 490-6
16. Halogenated chalcones with high-affinity binding to P-glycoprotein: potential modulators of multidrug resistance.
Bois F, Beney C, Boumendjel A, Mariotte AM, Conseil G, Di Pietro A
(1998) J Med Chem 41 : 4161-4
1997 [Top] 3
15. Binding of steroid modulators to recombinant cytosolic domain from mouse P-glycoprotein in close proximity to the ATP site.
Dayan G, Jault JM, Baubichon-Cortay H, Baggetto LG, Renoir JM, Baulieu EE, Gros P, Di Pietro A
(1997) Biochemistry 36 : 15208-15
14. Mutagenesis of charged residues in a conserved sequence in the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
Bertrand L, Vertommen D, Feytmans E, Di Pietro A, Rider MH, Hue L
(1997) Biochem J 321 ( Pt 3) : 609-14
13. Site-directed mutagenesis of Lys-174, Asp-179 and Asp-191 in the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
Bertrand L, Deprez J, Vertommen D, Di Pietro A, Hue L, Rider MH
(1997) Biochem J 321 ( Pt 3) : 623-7
1996 [Top] 2
12. The ATP-binding site in the 2-kinase domain of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Study of the role of Lys-54 and Thr-55 by site-directed mutagenesis.
Vertommen D, Bertrand L, Sontag B, Di Pietro A, Louckx MP, Vidal H, Hue L, Rider MH
(1996) J Biol Chem 271 : 17875-80
11. Recombinant N-terminal nucleotide-binding domain from mouse P-glycoprotein. Overexpression, purification, and role of cysteine 430.
Dayan G, Baubichon-Cortay H, Jault JM, Cortay JC, Deleage G, Di Pietro A
(1996) J Biol Chem 271 : 11652-8
1994 [Top] 2
10. Overexpression and purification of the carboxyl-terminal nucleotide-binding domain from mouse P-glycoprotein. Strategic location of a tryptophan residue.
Baubichon-Cortay H, Baggetto LG, Dayan G, Di Pietro A
(1994) J Biol Chem 269 : 22983-9
9. Preparation of highly phosphorylating mitochondria from the yeast Schizosaccharomyces pombe.
Jault JM, Comte J, Gautheron DC, Di Pietro A
(1994) J Bioenerg Biomembr 26 : 447-56
1993 [Top] 6
8. GTP binding to elongation factor eEF-2 unmasks a tryptophan residue required for biological activity.
Guillot D, Penin F, Di Pietro A, Sontag B, Lavergne JP, Reboud JP
(1993) J Biol Chem 268 : 20911-6
7. Intrinsic tryptophan fluorescence of rat liver elongation factor eEF-2 to monitor the interaction with guanylic and adenylic nucleotides and related conformational changes.
Sontag B, Reboud AM, Divita G, Di Pietro A, Guillot D, Reboud JP
(1993) Biochemistry 32 : 1976-80
6. Functional nucleotide-binding domain in the F0F1-ATPsynthase alpha subunit from the yeast Schizosaccharomyces pombe.
Falson P, Penin F, Divita G, Lavergne JP, Di Pietro A, Goody RS, Gautheron DC
(1993) Biochemistry 32 : 10387-97
5. Structural mapping of catalytic site with respect to alpha-subunit and noncatalytic site in yeast mitochondrial F1-ATPase using fluorescence resonance energy transfer.
Divita G, Goody RS, Gautheron DC, Di Pietro A
(1993) J Biol Chem 268 : 13178-86
4. Glutamine 170 to tyrosine substitution in yeast mitochondrial F1 beta-subunit increases catalytic site interaction with GDP and IDP and produces negative cooperativity of GTP and ITP hydrolysis.
Jault JM, Divita G, Allison WS, Di Pietro A
(1993) J Biol Chem 268 : 20762-7
3. Chemical modification of alpha-subunit tryptophan residues in Schizosaccharomyces pombe mitochondrial F1 adenosine 5'-triphosphatase: differential reactivity and role in activity.
Divita G, Jault JM, Gautheron DC, Di Pietro A
(1993) Biochemistry 32 : 1017-24
1992 [Top] 2
2. Differential nucleotide binding to catalytic and noncatalytic sites and related conformational changes involving alpha/beta-subunit interactions as monitored by sensitive intrinsic fluorescence in Schizosaccharomyces pombe mitochondrial F1.
Divita G, Di Pietro A, Roux B, Gautheron DC
(1992) Biochemistry 31 : 5791-8
1. Histone H1a subtype presents structural differences compared to other histone H1 subtypes. Evidence for a specific motif in the C-terminal domain.
Baubichon-Cortay H, Mallet L, Denoroy L, Roux B
(1992) Biochim Biophys Acta 1122 : 167-77